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涓婃捣鍚夌埦鐢熷寲鏈夐檺鍏徃
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鍚夌埦鐢熷寲锛堜笂娴凤級鏈夐檺鍏徃鏄敱鍦嬮殯鐭ュ悕钘ョ墿鍖栧(xu茅)瀹�銆佺編鍦嬮夯鐪佸ぇ瀛�(xu茅)鍠不路鎳风壒鏁欐巿鍙婂叐浣嶇暀缇庡崥澹Κ鑷弮鑸囩祫寤虹殑锛屾槸涓€瀹朵互澶氳偨銆佸鑲藉師鏂�銆佸鑲藉悎鎴愭柟娉曞(xu茅)鐐洪噸榛炵櫦(f膩)灞曢牁(l菒ng)鍩熺殑澶栧晢鐛ㄨ硣浼佹キ(y猫)銆�
涓昏鐢�(ch菐n)鍝�
澶氳偨
澶氳偨钘ョ墿
澶氳偨瑭﹀姂
绺悎鍔戔€斺€擝OP reagent, PyBOP, HBTU, TBTU, HOBt,EDC路HCl...
淇濊(h霉)鍔戔€斺€擣moc-OSu, Fmoc-Cl, Z-OSu...
鐢ㄤ簬鍥虹浉鍚堟垚鐨勯張鎺ュ姂鈥斺€擠HP linker, HMP linker, Sieber linker, Rink amide
linker, Weinreb amide linker...
Boc-姘ㄥ熀閰�锛孎(xi脿n)moc-姘ㄥ熀閰�锛孼-姘ㄥ熀閰�
闈炲ぉ鐒舵皑鍩洪吀
Fmoc-姘ㄥ熀閰哥帇妯硅剛
鑷�1998骞存垚绔嬩互渚�锛屽悏鐖剧敓鍖栫稉(j墨ng)姝蜂簡蹇€熺殑鐧�(f膩)灞曘€傚叕鍙告啈鍊熶竴鎵瑰劒(y艒u)绉€鎶€琛�(sh霉)楠ㄥ共鍜岄珮绱氱鐞嗕汉鎵�锛屽揩閫熸噳(y墨ng)灏嶅湅闅涘競鍫撮渶姹�锛岀爺绌堕枊鐧�(f膩)浜嗕竴绯诲垪鐨勬柊鐢�(ch菐n)鍝併€傜壒鍒ユ槸鍚勯澶氳偨瑭﹀姂锛屽凡缍�(j墨ng)鍦ㄥ湅闅涘競鍫翠笂寰楀埌浜嗗唬娉涚殑瑾�(r猫n)鍙�銆傜洰鍓�锛屽叕鍙稿張鍦ㄤ腑鍦嬪競鍫存帹鍑轰簡澶氳偨鍚堟垚妤�(y猫)鍕�(w霉)锛屽苟绌嶆サ璩囧姪鍜屽弮鑸囦腑鍦嬬殑澶氳偨瀛�(xu茅)琛�(sh霉)娲诲嫊锛屾帹鍕曚腑鍦嬪鑲戒簨妤�(y猫)鐨勭櫦(f膩)灞�銆�
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绺介儴浣嶄簬涓婃捣銆佸缓绛戦潰绌�35000骞虫柟绫�銆佹搧鏈�1000澶氬悕鍝″伐銆佺敱涓€鎵规捣鍏�(n猫i)澶栭爞绱氬崥澹皥瀹跺湗(tu谩n)闅婇牁(l菒ng)閵滅殑鍚夌埦鐢熷寲鏄竴瀹跺湅闅涢牁(l菒ng)鍏堢殑淇濊(h霉)姘ㄥ熀閰�銆佸鑲藉強鎶楅珨鐢�(ch菐n)鍝佺殑瑕�(gu墨)妯＄敓鐢�(ch菐n)浼佹キ(y猫)銆�
瑭曡珫锛氫笂娴峰悏鐖剧敓鍖栨湁闄愬叕鍙� (娉�:妯�(bi膩o)椤屽拰鍏�(n猫i)瀹归兘鏄繀闋堝～鐨�)
1.鐧�(f膩)甯冮張鎺ュ唬鍛婃垜鍊戞槸涓嶆渻瀵╂牳閫氶亷鐨�. 2.灏嶅叕鍙告眰鑱锋噳(y墨ng)鑱樼殑淇℃伅璜嬬洿鎺ヨ伅(li谩n)绯诲叕鍙�. 3.璜嬩笉瑕佺櫦(f膩)甯冮仌鍙嶆硶寰嬪拰閬撳痉搴曠窔鐨勬枃瀛�.
1.鐧�(f膩)甯冮張鎺ュ唬鍛婃垜鍊戞槸涓嶆渻瀵╂牳閫氶亷鐨�. 2.灏嶅叕鍙告眰鑱锋噳(y墨ng)鑱樼殑淇℃伅璜嬬洿鎺ヨ伅(li谩n)绯诲叕鍙�. 3.璜嬩笉瑕佺櫦(f膩)甯冮仌鍙嶆硶寰嬪拰閬撳痉搴曠窔鐨勬枃瀛�.
缍�(w菐ng)瑭曪細涓婃捣鍚夌埦鐢熷寲鏈夐檺鍏徃鍧愯惤浜庝腑鍦� 涓婃捣 涓婃捣甯�
涓婃捣绱绉戝(xu茅)鍦掔传鏈堣矾519铏�,涓荤嚐琛屾キ(y猫)鏄寲瀛�(xu茅)瑭﹀姂銆�
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澶╂触甯傛(bi膩o)婧�(zh菙n)绉戞妧鏈夐檺鍏徃
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钀嘲鐢熺墿绉戞妧鍏徃
鎴愰兘浜戦椿绉戞妧鐧�(f膩)灞曟湁闄愬叕鍙�
鍖椾含鏄ョ敨鎳�(y墨ng)鐢ㄦ妧琛�(sh霉)鐮旂┒涓績
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娌冲寳楱扮鍖栧伐鏌撴枡鍥炴敹鏈夐檺鍏徃
娣卞湷甯傛櫘缇庨仈(d谩)绉戞妧鏈夐檺鍏徃
鍖椾含鍔涢€旂鎶€鏈夐檺鍏徃
鎴愰兘宸濇姉娲惧痉鐢熺墿閱�(y墨)钘ョ鎶€鏈夐檺鍏徃
寤ｅ窞甯傜稜搴风敓鐗╃鎶€鏈夐檺鍏徃
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鎻愪氦澶辨晽璜嬭伅(li谩n)绯绘垜鍊�
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